![]() ![]() A multidrug screening is identifying compounds that can regulate this process and may serve as potential agents to treat osteoporosis. He has used age- and radiation-related bone marrow adiposity in vivo and in vitro to determine if senescence plays a role in MSC depletion due to fate conversion to adipocytes. Information provided by (Responsible Party). Chandra utilizes lineage-tracing methods to accurately characterize the mesenchymal fate and identify the pathways that regulate cell fate. Safety Study of Adult Mesenchymal Stem Cells (MSC) to Treat Acute Myocardial Infarction. His research aims to define the cues that regulate mesenchymal cell fate and assign them to an osteogenic or adipogenic fate. Mesenchymal stem or stromal cells (MSCs) have been administered in hundreds of clinical trials for multiple indications, making them some of the most commonly used selected regenerative cells. Mesenchymal stem cells (MSCs) self-renewal capacity is characterized by their ability to divide and develop into multiple specialized cell types in a specific tissue or organ. Chandra focuses on therapeutic options to regulate bone marrow adiposity. Multipotent mesenchymal stromal cells, more commonly known as mesenchymal stem cells (MSCs), are adult stem cells with a set of characteristic properties. Mesenchymal stem cells are adult stem cells that have self-renewal, immunomodulatory, anti-inflammatory, signaling, and differentiation properties. The prevailing dogma has been that allogeneic MSCs. Allogeneic MSCs are especially attractive due to their potential to provide immediate care at the time of tissue injury or disease diagnosis. This is one major reason bones fail to regenerate in osteoporotic conditions.ĭr. Autologous and allogeneic adult mesenchymal stem/stromal cells (MSCs) are increasingly being investigated for treating a wide range of clinical diseases. However, there is still very little knowledge available that documents the properties of a MSC in its native environment. Intriguingly, the depletion in functional MSCs often correlates with the increase in adiposity. A considerable amount of retrospective data is available that describes putative mesenchymal stem cells (MSCs). Bone marrow has a limited MSC pool that depletes with age and after disease. Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including bone cells (osteoblasts), cartilage cells (chondrocytes), muscle cells (myocytes) and fat cells that give rise to marrow adipose tissue (adipocytes).
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